Saint John of Las Vegas

Steve Buscemi

John

Romany Malco

Virgil

Sarah Silverman

Jill

Peter Dinklage

Mr. Townsend

Tim Blake Nelson

Ned

John Cho

Smitty

Emmanuelle Chriqui

Tasty D Lite

Matthew McDuffie

Lucypher

Jesse García

Park Ranger

Ben Zeller

Truck Stop Owner

Aviva Baumann

Pennie

Danny Trejo

Bismarck

Stephen Eiland

Mordicai

Shawn Prince

Ticket Taker

Josh Berry

Manager

Jim Giesler

Barker

Isabel Archuleta

Vegas Counter Girl

Isaac Kappy

Geek

Gorneth D'Oyley

Dealer

Ernest Labreck

Ed MacMahon Type